Reference: Cain is a reference to the Biblical story of Cain and Abel, in which Cain commits the first murder by killing his brother Abel. Also, the LUCK FOOT lowers your chance of getting a bad pill effect, and makes your chance games chances higher Ups/Downs: Besides his hearts, he starts out with great stats. I made the difficulty a 3, because the temptation to buy something at a shop is extremely strong Don’t buy anything in the stores or play any games in the arcade. Strategy: Use bombs to get pennies that you can’t reach otherwise. Unlock: Obtaining 55+ pennies at once in a run. She has been canonized as a saint in several christian denominations, and she has been traditionally depicted as a prostitute before following Jesus. Reference: Maggie is a reference to Mary Magdalene, a follower of Jesus. For the later levels, hope that you get some speed items, because Maggie is very slow. It is very difficult for her to die on the first 2 floors due to the healing power of her YUM HEART and base 4 heart containers. Ups/Downs: She is a great character to start with when you aren’t very good at the game yet. It all depends on what items you get in a run 
Unlock: Obtain 7+ heart containers in one run.Reference: Reference to the biblical story The Binding of Isaac, in which Abraham is commanded by God to sacrifice his only son, Isaac, in order to prove his loyalty.
The pictures and references come from the Binding of Isaac: Rebirth Wiki
#The binding of isaac rebirth how to#
For each character (besides Isaac), I will be laying out how to unlock them, the strategy I used, their stats, their ups and downs, and where their name comes from. With the recent release of The Binding of Isaac: Rebirth, and the fact that I have to do a “How-To” post for class, I figured this would be the perfect post. How To Unlock Characters in Binding of Isaac: Rebirth
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